Ole Gunnar Solskjaer’s men travel to the Molineux, where Nuno Espirito Santo’s side have established themselves as the best team outside the Big Six.
Wolves have taken points off every one of the big boys in the league this season, including a 1-1 draw in Old Trafford in September.
Speaking of the Black Country side’s emergence after promotion, Solskjaer said: “That’s a testament of them. You can see that now in seventh [they] trust their own way of playing.
“They defended fantastically well against Chelsea [in a 1-1 draw last week] but at home they take the game to the opponent with the great passing ability.”
Solskjaer’s men kick-off in the tie of the round at 7.55pm tonight, while local rivals Manchester City take on Swansea at the peculiar time of 5.20pm.
Pep Guardiola’s side are primed for a quadruple and are expected to sweep aside Championship Swansea, who are hoping for a memorable night at the Liberty Stadium.
After the ties are done, all eyes will be on who plays who at Wembley in the semi-finals – here’s all you need to know…
FA Cup semi-final draw – when is it?
The draw for the semi-finals of the FA Cup will take place on Sunday on BBC One, immediately after Millwall vs Brighton.
That game kicks off at 2pm, so if the game is finished within normal time it should take place around 4pm.
Leon Osman and Jimmy Floyd-Hasselbaink will conduct the draw.
FA Cup semi-final draw – ball numbers
1 – Swansea or Man City
2 – Watford or Crystal Palace
3 – Wolves or Man Utd
4 – Millwall or Brighton
FA Cup semi-final draw – when will the ties take place?
Semi-final ties will take place at Wembley Stadium on Saturday 6 April and Sunday 7 April.
The final is scheduled to be played on Saturday 18 May.