The task does not get any easier after the Catalans, as the Red Devils will then face either Liverpool or Porto in the semi-finals.
Should United make it past both of those ties, they will reach their first final since 2011 – but not in ideal circumstances.
That is because one of the many draws which took place at Nyon decided which side of the draw would enter Atletico Madrid’s Wanda Metropolitano stadium as the home team.
As a result, one of Manchester United, Liverpool, Barcelona or Porto will play the final as the away team.
Although seemingly an trivial administrative obligation, being drawn as the home team will mean reaping the benefits of Atletico Madrid’s state-of-the-art bowl dressing room.
The away dressing is not as big or modern, giving United and the three other sides what could be perceived as a slight disadvantage on the night.
Uefa warned of that possibility before the draw, saying: “Manchester City and Manchester United will not be able to play at home on the same night, nor on consecutive nights, following a decision made by the relevant local authorities.
“Therefore, should both clubs be drawn at home in the same week, the team having finished lower in the domestic league the previous season – in this case Manchester United – will be reversed in accordance with the UEFA Club Competitions Committee principles.”