De Bruyne doesn’t think Liverpool are going to drop any more points this season with four league games left to play.
As a result the Belgian thinks City will need to win all of their remaining games, if they are to win the title.
City find themselves two points off league leaders Liverpool, but winning their game in hand will take them back to the top of the table, with a one point lead.
Pep Guardiola’s side are still on for the quadruple this season but they have a congested fixture list as the end of the season closes in.
“We’ll probably have to win every game to win the title from here,” De Bruyne said.
“We can only control what we’re doing, but we’re still there and doing really well.”
City face a double-header against Tottenham next, with the second leg of their Champions League quarter-final clash coming up tomorrow night before they host Spurs again in the league on Saturday.
Spurs will be without Harry Kane, who suffered a “significant” ankle injury in the Champions League quarter-final first leg last week.
But De Bruyne isn’t writing off Spurs despite them being without their top goal scorer.
“Harry Kane is a wonderful striker, but it would be disrespectful to the other guys [to write them off],” he said.
“They won against us without him when he went off last week and they have brilliant players.
“Earlier they won so many games without him before and they are still a very good team without him.
“Obviously he’s a really good player, but it’s not going to change anything.
“It will be a great game, a good atmosphere and, hopefully, a good game. For us it’s all or nothing.”
City are trying to win back-to-back Premier League titles this season – a feat last achieved by rivals Manchester United in 2007/08 and 2008/09.
De Bruyne, who has been limited to only 15 appearances in the league this campaign because of injuries, feels City can be positive about their season even if they don’t retain the title.
“If we don’t win the Premier League, people are going to say it’s a failure,” he said.
“And even if we don’t make it, I think we’ll still have had a great season.”