The Reds welcome Pep Guardiola’s side to Anfield on Sunday (4.30pm) in a huge match in the race for the title.
Klopp’s Reds are currently six points clear at the top of the table having been unbeaten in their first 11 games this campaign.
Oxlade-Chamberlain was named Liverpool’s player of October after making three appearances, starring in each of them.
Jordan Henderson missed the Champions League match with Genk in midweek due to illness and there was thoughts that Oxlade-Chamberlain could replace the captain.
However Henderson is back to fitness and likely to keep his place.
It means Oxlade-Chamberlain may have to cope with a place on the bench with Fabinho and Georginio Wijnaldum likely to join Henderson in midfield.
In defence, Joel Matip is out injured due to a knee issue meaning Dejan Lovren is likely to get the nod over Joe Gomez alongside Virgil van Dijk.
Klopp said: “Joel [Matip] is still out, like Shaq and like Clyney. That’s it, probably.”
That means it will more than likely be Mohamed Salah, Roberto Firmino and Sadio Mane in attack.
Klopp added: “You cannot make games bigger than they are already. It’s a very important game. A very, very important game.
“But we cannot make it more important than very, very important.”
Liverpool predicted line-up vs Man City – Premier League
(4-3-3) Alisson; Alexander-Arnold, Lovren, Van Dijk, Robertson; Fabinho, Henderson, Wijnaldum; Salah, Firmino, Mane.