Neymar will miss around 10 weeks of action thanks to a metatarsal injury.
The Brazilian, along with Kylian Mbappe and Edinson Cavani, who also misses out through injury, form one of the most formidable front three in world football.
But tonight at Old Trafford, only one third of them will be playing.
“I would say we are lucky that Neymar is not there – it’s unlucky for him, but lucky for us because he’s a player that can change the game by himself as well,” he told the official club website.
“Those kinds of players, you don’t really know where or how to block them, because they can create so much space, they can dribble [past] two players, they can score goals.
“They are all dangerous, so you don’t think about only one player, because it’s always a team.
“But obviously their attack is the key. So hopefully we’re gonna block them.”
When PSG and United were drawn together in December, not many gave the Manchester team a hope of advancing to the quarter-finals of Europe’s elite competition.
But Ole Gunnar Solskjaer, who took over as caretaker boss following Jose Mourinho’s sacking, has led United to 10 wins from 11 games.
Pogba’s form has been one of the biggest positives for United, and now he’s looking forward to playing against his hometown team.
“Coming from Paris, and playing against your ‘home’ or your first town, it’s my first time, so it’s going to be beautiful! I’m going to have my family around, all my friends. But I hope we win,” he said.
“There are a lot of French players, and they have top players who have been winning the league for I don’t know how many years.
“They’re looking to win the Champions League – that’s their goal. The goalkeepers, Alphonse Areola, Gigi [Buffon] – I played with both of them, and Kylian [Mbappe] and [Presnel] Kimpembe.
“So I’m looking forward to playing against them, but the first thing is to win against them! That’s what I want.”
United were knocked out of the Champions League by Sevilla at this very stage last year.